Hepatoma-associated antigens and host reactivity to hepatoma

Doxorubicin conjugates of monoclonal antibodies to hepatoma-associated antigens.

A panel of six murine monoclonal antibodies against hepatocellular carcinoma-associated antigens, reactive with PLC/PRF/5 human hepatoma cells, was conjugated to Adriamycin (doxorubicin) via a dextran bridge. This library of antibodies includes three monoclonal antibodies against hepatitis B virus surface antigen, one anti-alpha-fetoprotein, and two other IgG2a antibodies against PLC/PRF/5 hepa...

Right Atrial Maass Associated with Hepatoma

Cirrhosis and hepatoma in alcoholics.

The cause of cirrhosis in alcoholics is unknown but nutritional deficiencies have been invoked as being important, largely on the basis of experimental work in animals. This includes the production of fatty liver and cirrhosis in rats by diets deficient in lipotropic substances such as choline and methionine (Blumberg and McCollum, 1941) and by low-protein diets (Rich and Hamilton, 1940). The r...

Hepatoma HTC-SR Cells

A growth factor has been isolated from HTCSR rat hepatoma tissue culture cells which specifically stimulates DNA synthesis and cell proliferation of the HTC cells that produce it. The factor can be isolated from HTC cell conditioned medium or from an HTC cell extract. This autocrine factor has been purified 640-fold from a postmicrosomal supernatant by successive steps, involving ethanol precip...

Expression of CXC Chemokines Gro/KC and SDF-1a in Rat H4 Hepatoma Cells in Response to Different Stimuli

Background: It is now well established that several environmental stress factors cause activation of p38 MAP kinase and JNK in various cell types to produce chemokines. Objective: To investigate the expression of CXC chemokines Gro/KC and SDF- 1a in rat's H4 hepatoma cells in response to heat shock, hyperosmolarity and oxidative stress. Methods: Hepatoma cells were maintained in MEM medium. Cel...